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Stereotactic Radiosurgery for Intracranial Meningiomas: Current Concepts and Future Perspectives

Mansouri, Alireza MD; Guha, Daipayan MD; Klironomos, George MD, PhD; Larjani, Soroush BSc; Zadeh, Gelareh MD, PhD; Kondziolka, Douglas MD, Msc

Neurosurgery 76:4:362–371, 2015. doi: 10.1227/NEU.0000000000000633

Link to free article: http://journals.lww.com/neurosurgery/Fulltext/2015/04000/Stereotactic_Radiosurgery_for_Intracranial.12.aspx


Meningiomas are among the most common adult brain tumors. Although the optimal management of meningiomas would provide complete elimination of the lesion, this cannot always be accomplished safely through resection. Therefore, other therapeutic modalities, such as stereotactic radiosurgery (as primary or adjunctive therapy), have emerged. In the current review, we have provided an overview of the historical outcomes of various radiosurgical modalities applied in the management of meningiomas. Furthermore, we provide a discussion on key factors (eg World Health Organization grade, lesion size, and lesion location) that affect tumor control and adverse event rates. We discuss recent changes in our understanding of meningiomas, based on molecular and genetic markers, and how these will change our perspective on the management of meningiomas. We conclude by outlining the areas in which knowledge gaps persist and provide suggestions as to how these can be addressed.


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